The business-to-business commerce landscape is undergoing its most fundamental transformation since EDI (Electronic Data Interchange) standardized supply chain communications in the 1980s. With Google's April 2025 launch of the Agent2Agent (A2A) protocol—backed by 50+ enterprise partners including Salesforce, SAP, ServiceNow, and PayPal—we're witnessing the birth of a new paradigm: agent-mediated commerce.
This isn't about chatbots processing orders. It's about autonomous AI agents discovering suppliers, negotiating terms, executing purchases, and managing fulfillment—all without human intervention for routine transactions. The infrastructure required to enable this shift represents a massive greenfield opportunity.
The thesis: Whoever builds the trust, discovery, and settlement layers for agent-to-agent commerce will capture outsized value in the $12 trillion global B2B e-commerce market.

